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Unexplained splenic infarct

Splenic infarction: an update on William Osler's observation

Conclusions: The clinical presentation of splenic infarction in the modern era differs greatly from the classical teaching, regarding etiology, signs and symptoms. In patients with unexplained splenic infarction, investigation frequently uncovers a new underlying diagnosis Splenic infarction and splenic vein thrombosis are rare causes of abdominal pain, usually presenting as left-sided abdominal pain associated with fever, nausea or vomiting, and elevated white blood cell count. CT scan is currently the preferred diagnostic test The differential diagnosis of unexplained fever and splenic infarcts in an immunocompetent patient would include embolic events due to endocarditis; viral infections, such as with Epstein-Barr virus and CMV; infectious vasculitis, as observed in neisserial infections; and noninfectious etiologies, including sickle-cell disease, autoimmune. Although splenic infarction is rare, it is a recognized and dramatic complication of sickle cell trait (Am J Med 1989;87:30-4). Splenic infarction usually causes pain in the left upper quadrant of the abdomen, although the pain is occasionally referred to the shoulder

Etiology and Management of Splenic Infarction and Splenic

  1. INTRODUCTION. Splenic infarction (SI) occurs when the splenic artery or 1 or more of its branches become occluded, either by an embolus or by in situ thrombosis. 1 The spleen has a rich vascular supply and receives 5% of the cardiac output making it susceptible to emboli (cardiogenic, aortic, paradoxical). 2 Furthermore, it is not infrequently affected by malignant hematological disorders.
  2. al pain (up to 70%). Additional symptoms include fever and..
  3. Actually, most of the cases of primary splenic FL reported by Mollejo et al were characterized by BCL2 and/or CD10 negativity (8 of 9 cases and 4 of 9 cases, respectively) and by the absence of BCL2 translocation (8 of 8 cases), as well as by a high proliferation index (7 of 9 cases) and rate of transformation toward DLBCL (3 of 8 cases). 22.
  4. Splenic abscess can result from septic emboli or superinfection of a prior infarct. Traditionally, such abscesses have been managed by means of splenectomy, which can be technically challenging..

Deep vein thrombosis or pulmonary embolism is more common in immunocompetent patients while splenic infarct is more common in immunocompromised patients. However, here we report a female patient on low-dose methotrexate for rheumatoid arthritis who presented with both pulmonary embolism and splenic infarct. 1 Atrial Fibrillation and Splenic Infarction Presenting with Unexplained Fever and Persistent Abdominal Pain-A Case Report and Review of the Literature. Acta Cardiol Sin 2012;28:157-160 3. Meir Antopolsky, Nurit Hiller, Shaden Salameh, Beth Goldshtein, Ruth Stalnikowicz Beeson MS. Splenic infarct presenting as acute abdominal pain in an older patient. J Emerg Med 1996; 14:319. Görg C, Seifart U, Görg K. Acute, complete splenic infarction in cancer patient is associated with a fatal outcome. Abdom Imaging 2004; 29:224. Nores M, Phillips EH, Morgenstern L, Hiatt JR. The clinical spectrum of splenic infarction

Unexplained fever accompanied by splenic infarcts in an immunocompetent patient can be seen in endocarditis, in viral infections such as EBV, in infectious vasculitis as observed in neisserial infections, and in various other non-infectious conditions, including sickle-cell anemia, autoimmune vasculitis and hypercoagulable states [ 2 ] In this case CMV infectious mononucleosis was accompanied by procoagulant activity which resulted a DVT, pulmonary emboli and splenic infarct. We believe this to be the first reported case of CMV infectious mononucleosis splenic infarct in a patient with a history of sarcoidosis Splenic infarction (SI) occurs mostly in individuals with the aforementioned predisposing factors. Untreated, splenic infarct can result in the development of splenic abscess or pseudocyst, or it may cause hemorrhage with subsequent splenic rupture. Thus, it is important for clinicians to maintain a high index of suspicion for splenic infarct in patients with diseases known to be associated with this complication who present with unexplained chest pain Splenic infarction is an uncommon antemortem diagnosis. The clinical presentation can mimic other causes of acute abdominal pain. A review of the literature revealed a few series of splenic infarction, Splenic infarcts are rare conditions where a portion of the spleen necrotizes or dies. This happens when the blood supply is compromised, usually as a result of trauma or arterial blockages

Ovarian Clear Cell Carcinoma Presenting as Non-bacterial

45-Year-Old Woman with Fever and Splenic Infarcts

Splenic infarction (, Fig 28) and fibrosis may also demonstrate a multifocal pattern. Miscellaneous Conditions.—Sarcoidosis is a multisystem granulomatous disease of unknown origin. Abdominal involvement is uncommon during the first decade of life but may be seen in adolescents (, 56) showed unexplained splenic infarcts. One additional patient was diagnosed with ischemic colitis through endoscopy (Supplementary Figure 2). D-dimer was tested in 6 patients and results were markedly elevated in all of them. Six of 7 patients also underwent a thoracic computed tomography scan that showed pulmonary thromboembolism in 1 patient Splenic infarct is a rare but documented complication in COVID-19-infected patients in both clinical and autopsy studies [4-10]. Incidence in non-COVID patients is estimated at 0.016%. Splenic infarct is often found incidentally and partially imaged on CT scans of the chest, as in this case

Cytomegalovirus (CMV) infection generally causes asymptomatic infection in the majority of immunocompetent individuals. However, the presentation may be complicated by life-threatening conditions in immunocompromised patients. We report a case of a 23-year-old healthy Caucasian female with acute CMV infection and splenic infarction. Serological studies confirmed acute CMV infection, and. Spleen injuries are among the most frequent trauma-related injuries. At present, they are classified according to the anatomy of the injury. The optimal treatment strategy, however, should keep into consideration the hemodynamic status, the anatomic derangement, and the associated injuries. The management of splenic trauma patients aims to restore the homeostasis and the normal physiopathology. splenic infarct in patients with diseases known to be associated with this complication who present with unexplained chest pain. Figure 1. Splenic infarction (arrow) on axial section of contrast enhanced computed tomography of abdomen. Pa S (21) Splenic infarct presenting as acute chest pai

A Case of Splenic Infarction at High altitude in Sickle

Acute splenic infarction CMA

Splenic infarction refers to the rare condition resulting in the death of your spleen portion. The spleen necrotizes due to the problem with the blood supply. You can experience a compromise in blood supply due to arterial blockages or trauma. Cause Of Splenic Infarction. The common factors leading to the splenic infarction are Splenic infarction: past health history is usually positive for blood disorders (hemoglobinopathies, myeloproliferative disorders), 3. Splenic artery aneurism ready to rupture: in this case the patient usually has a recent pregnancy, and the pain is dull but with continual worsening, till the final clinical manifestation of hemoperitoneum and. Splenic infarcts were seen in 10.2% of the autopsies, hepatic infarcts in 3.3%, and BCS in 1.6%. Abdominal involvement was the cause of death in 4 (4.9%) patients (3 patients with liver failure and 1 patient with acute abdomen) [ 124 , 125 ] Atrial Fibrillation and Splenic Infarction Presenting with Unexplained Fever and Persistent Abdominal Pain-A Case Report and Review of the Literature. Acta Cardiol Sin 2012;28:157-160 3. Meir Antopolsky, Nurit Hiller, Shaden Salameh, Beth Goldshtein, Ruth Stalnikowicz. Splenic infarction: 10 years of experience. American Journal of Emergency.

Acute Splenic Infarction at an Academic General Hospital

Ecchymosis & Splenic Infarction Symptom Checker: Possible causes include Primary Myelofibrosis. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search -splenic infarcts. What are the clinical presentations of polycythemia vera?-weakness-fatigue-vertigo-tinnitus-irritability-splenomegaly -unexplained weight loss-loss of appetite-itching. What is the most common cause of splenic abscess? subacute bacterial endocarditis INTRODUCTION: There is an awareness of the increased incidence of splenic abscess in Southeast Asia giving rise to unexplained fever. This study looks at the role of computed tomography (CT) in evaluating focal splenic lesions in patients presenting with fever Heparin-induced thrombocytopenia with thrombosis (HITT) is a paradoxical prothrombotic complication of anticoagulant therapy. As many as 3% of patients undergoing cardiac surgery develop clinical HIT presenting as thrombocytopenia with or without thrombosis within 5-10 days of heparin exposure. Thrombotic complications associated with HIT carry a mortality rate of 5-10% Lesser hemorrhage causes left upper quadrant abdominal pain, which sometimes radiates to the left shoulder. Patients with unexplained left upper quadrant pain, particularly if there is evidence of hypovolemia or shock, should be asked about recent trauma. Maintain a high index of suspicion for splenic injury in patients who have left rib fractures

Video: Splenic Infarct Clinical Presentation: History and

Abdominal pain and cramping are among possible symptoms of a splenic artery aneurysm. Abdominal aneurysms, involving blood vessels in the abdomen, are often very serious because the largest vessels in the body are in the abdomen, and many supply multiple organs. People with unexplained abdominal pain should seek medical treatment, and a thorough diagnostic workup to learn more about the. Splenic infarction with sickle cell trait is usually self-limited, resolving in 10 to 21 days, and rarely requiring surgical intervention. Non-traumatic splenic infarction following altitude hypoxia is most likely to occur in people with sickle cell disease and an enlarged and functional spleen prior to exposure Liver involvement is often observed in several hematological disorders, resulting in abnormal liver function tests, abnormalities in liver imaging studies, or clinical symptoms presenting with hepatic manifestations. In hemolytic anemia, jaundice and hepatosplenomegaly are often seen mimicking liver diseases. In hematologic malignancies, malignant cells often infiltrate the liver and may. Conclusion: The present case raises awareness by highlighting an unexplained and unexpected splenic infarction association with P-MAIVF as a result of infective endocarditis related to mixed bicuspid aortic valve disease. Background: Pseudoaneurysm of the mitral-aortic intervalvular fibrosa (P-MAIVF) is an unusual complication related to. Splenic infarction may cause the spleen to appear less echogenic than normal. Color Doppler ultrasonography may demonstrate the absence of blood flow in the spleen and a high resistive index in the splenic artery in cases of torsion of a wandering spleen. In immunosuppressed patients with unexplained clinical deterioration, imaging studies.

due to splenic hematomas reported previously cleared only after splenectomy, suggesting splenectomy may be neces-sary to prevent reaccumulation. We propose possible path-ophysiologic mechanisms and recommend that splenic vein thrombosis be considered in the differential diagnosis of unexplained left-sided pleural effusions. (Chat 1991; 100:574-75 Splenic infarction as a rare complication of infectious mononucleosis due to Epstein-Barr virus infection in a patient with no significant comorbidity: case report and review of the literature. Gavriilaki E, Sabanis N, Paschou E, Grigoriadis S, Mainou M, Gaitanaki A, Skargani-Koraka Joazlina ZY, Wastie ML, Ariffin N Correspondence: Dr Joazlina Zaleha Yusof, joazliniazy@yahoo.com ABSTRACT Introduction There is an awareness of the increased incidence of splenic abscess in Southeast Asia giving rise to unexplained fever. This study looks at the role of computed tomography (CT) in evaluating focal splenic lesions in patients presenting with fever

How I diagnose and treat splenic lymphomas Blood

Splenic infarction - Causes. In a single-center retrospective cases review, people who were admitted to the hospital with a confirmed diagnosis of acute splenic infarction, cardiogenic emboli was the dominant etiology followed by atrial fibrillation, autoimmune disease, associated infection, and hematological malignancy. In spite of those already had risk factors of developing splenic. The spleen is one of the most frequently affected organs in sickle cell anemia (SCA). This study aims to characterize the spleen in sickle cell anemia patients using contrast enhanced computerized tomography scanning (CECT). 67 patients with SCA from different Saudi Arabian areas were enrolled; ages are ranged from 10 months to 28 years old Whipple disease is a rare bacterial infection that most often affects your joints and digestive system. Whipple disease interferes with normal digestion by impairing the breakdown of foods, and hampering your body's ability to absorb nutrients, such as fats and carbohydrates Cytomegalovirus-associated splenic infarcts in a female patient with Factor V Leiden mutation: a case report. Journal of Medical Case Reports, 2008. Tamar Chundadze. Yaron Arbel. Nili Saar. Tamar Chundadze. Yaron Arbel. Nili Saar. Download PDF. Download Full PDF Package. This paper

Gaucher disease type 1 often mimics the signs and symptoms of many hematological malignancies. It also may display inactive periods interrupted by episodes of acute crises or evidence of disease advancement. 3,4 Patients may appear to be asymptomatic, yet harbor mild disease manifestations such as cytopenia, splenomegaly, or osteopenia. 5 Unexplained fever accompanied by splenic infarcts in an immunocompetent patient can be seen in endocarditis, in viral infections such as EBV, in infectious vasculitis as observed in neisserial infections, and in various other non-infectious conditions, including sickle-cell anemia, autoimmune vasculitis and hypercoagulable states [2]

The differential diagnosis of unexplained fever and acute splenic infarction includes viral infectious causes such as acute EBV and acute CMV, infectious vasculitis as observed in neisserial infections; underlying myeloproliferative disorders such as Polycythemia rubra vera (PCV); underlying hemoglobinopathy especially sickle cell disease. infarction [in-fark´ shun] 1. infarct. 2. formation of an infarct. cardiac infarction myocardial infarction. cerebral infarction an ischemic condition of the brain, causing a persistent focal neurologic deficit in the area affected. myocardial infarction see myocardial infarction. pulmonary infarction localized necrosis of lung tissue caused by.

Fever that is unexplained and lasts for long durations. Temperatures over 38C (100.4F) usually seen. There may be pain in the abdomen due to splenic infarction. Enlarged lymph nodes may be noted Today it is indicated only in certain forms of hypersplenism or unexplained splenic enlargement. We consider the Moeschlin technique to be the safest. Splenic aspiration is contraindicated in patients with hemorrhagic diathesis, septic splenomegaly, splenic cysts, or painful splenomegaly due to excessive capsular tension or infarction

Sudden cardiac death (SCD) is the number one cause of exercise related death in young athletes and is due to a cardiovascular disorder. Age is a very significant factor in regards to SCD in athletes. For adults (individuals older than 35) coronary artery disease is the major cause of exercise r. Splenic infarcts, perisplenitis, or subcapsular haematoma may cause severe left upper quadrant or left shoulder pain. Spontaneous bleeding may occur and vary from insignificant cutaneous petechiae to severe, life-threatening gastrointestinal tract bleeding However, splenic infarction could cause destructive consequences such as hemorrhagic shock, especially in old or weak patients. In this article, we present one case with fever and unexplained abdominal pain; the patient was ultimately diagnosed spontaneous splenic infarction Infarction 25 (4.3%) Total 320 (54.7%) Table 3. Pathological findings in therapeutic splenectomies Indication Number (percentage) idiopathic thrombocytopenic purpura 113 (19.3%) splenic rupture 116 (19.8%) Total 229 (39.1%) Discussion There are many pathological conditions underlying unexplained splenomegaly or splenic mass. The most commo

Splenic Infarct Treatment & Management: Approach

Splenic Infarction Epidemiology and Pathogenesis . Splenic infarction, the result of arterial or venous compromise, has many potential causes, including hematologic disorders, thromboembolic disease, vascular diseases, and trauma ( Box 105-5 ). Although splenic infarction is a relatively common finding, only a few larger series have been. Spontaneous Splenic Infarction as an Uncommon Cause of Fever in ; Splenic Infarcts NCBI Bookshelf; Arterial thrombosis in unusual sites; Splenic Infarction 2020; A practical approach to infarction of the spleen as a rare ; Atrial Fibrillation and Splenic Infarction Presenting with Unexplained ; Radiology Reference Article Radiopaedia.or Percutaneous Transgastric-Transpancreatic Treatment of a Dissecting Splenic Artery PseudoaneurysmKumar et al. were noted to be present and remained unchanged. The right segmental renal infarct had remained stable, and the right renal artery appeared unremarkable. The patient was admit - ted for further work-up of the abnormal CT findings. Inflam

Splenic Infarct and Pulmonary Embolism as a Rare

Thus, in peritoneal dialysis patients with diffuse atherosclerosis or the risk of systemic embolization, symptoms of unexplained left upper quadrant pain and culture-negative peritonitis should be evaluated to rule out splenic infarction 1. After blunt splenic injury, clinical factors such as a persistent systemic inflammatory response, increasing/persistent abdominal pain, or an otherwise unexplained drop in hemoglobin should dictate the frequency of and need for follow-up imaging for a patient with blunt splenic injury. 2

Infarctul splenic - complicație a fibrilației atriale

≥3 unexplained consecutive spontaneous abortions† at or <10 WG Pulmonary: Pulmonary embolism Pulmonary artery thrombosis Gastrointestinal: Budd-Chiari syndrome Oesophageal ischaemia Hepatic vein thrombosis Mesenteric ischaemia Pancreatic infarction Splenic infarction Renal: Renal artery/vein thrombosis Dermatological Abdominal pain that steadily worsens over time, often accompanied by the development of other symptoms, is usually serious. Causes of progressive abdominal pain include: Cancer. Crohn's disease (a type of inflammatory bowel disease) Enlarged spleen (splenomegaly) Gallbladder cancer. Hepatitis Splenic infarction and or sequestration e.g. sickle cell disease. Assessing splenic function. There is no consensus regarding the best method for assessing splenic function and if there is concern regarding hyposplenism, a cautious approach and adherence to this guideline is recommended Splenic artery aneurysms are four times as common in women as they are in men, and the rate of rupture is particularly increased during pregnancy 62). Spontaneous rupture occurs in 3%-10% of splenic artery aneurysms and produces a high mortality rate, estimated to be approximately 36% 63) Hepatosplenomegaly refers to an enlargement of the liver and spleen. Its causes include a variety of conditions that affect these two organs, including liver disease, HIV, anemia, infections, and.

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Splenic abscess is widely known in the literature as a rare complication of infective endocarditis. Rapid diagnosis and treatment are essential as its course can prove fatal. We present a case-report of splenic abscess in patients who were initially diagnosed with infective endocarditis pain and unexplained abdominal *Corresponding author Email: amalankouz@yahoo.fr 1 University Hospital Center Hassan II, Fez, Morocco splenic collections suggestive of splenic Figure 1: CT scan of the abdomen showing two encapsulated hyperintense abscesses

Cytomegalovirus-associated splenic infarcts in a female

An Infection of the inner layers of the heart most commonly involving the valves. Infection can lead to destruction of the valve resulting in a number of cardiac complications including valvular insufficiency, heart failure, heart block, death. In addition, valve destruction and infection can cause embolism's which can cause complications. section extended into adjacent splenic and proximal hepatic arteries (Fig. 2). Viscera were affected in two of six patients. One pa-tient had splenic infarction 6 days after ini-tial presentation (Fig. 3). A second patient experienced bilateral re-nal infarction 5 days after initial presentation (Fig. 4). Although the aorta and main rena To evaluate the role of partial splenic artery embolization in corpuscular correction in cirrhotic patients. Bleeding tendency was experienced in two thirds of patients (66.7%) and anemia in 63.3%. Splenic size ranged from 14.3 to 22 cm. PV diameter ranged from 11 to 18 mm. The mean platelet at the pre-operative laboratory was 34.9 ± 10.3 × 103, corrected to 137.6 ± 37.1 × 103 within 1. The combination of unexplained epigastric pain and elevated lactate dehydrogenase and haematuria in a patient with an increased risk of thromboembolic events should raise the suspicion of acute kidney infarction. such as mesenteric ischaemia and splenic infarction [7]

Sarcoidosis with fever and a splenic infarct due to CMV or

Trousseau's syndrome is a cancer-associated thrombosis. Trousseau's syndrome with cholangiocarcinoma is a rare condition with poor prognosis. A 59-year-old female was admitted to our hospital with abdominal pain, headache, and nausea. Abdominal enhanced computed tomography revealed liver tumor, splenic infarction, and bilateral renal infarction cerebral ischaemic infarcts, as well as an acute kidney injury driven by rhabdomyolysis. The following day, bilateral lower limb ischaemia was observed. A full body CT angiogram revealed a complete thromboembolic shower with bilateral arterial occlusion in the lower limbs, bilateral pulmonary emboli, a splenic infarct and mesenteric ischaemia Splenic infarcts usually appear as wedge-shaped or rounded hypoechoic areas on ultrasonography.24 Rests of preserved splenic tissue or regrowth of splenic tissue occasionally may also be seen as hypoechoic areas in patients with SCD.25 In one study, splenomegaly was detected in 15 patients (17.9%). Shrunken spleen wa

After blunt splenic injury, clinical factors such as a persistent systemic inflammatory response, increasing/persistent abdominal pain, or an otherwise unexplained drop in hemoglobin should dictate the frequency of and need for follow-up imaging for a patient with blunt splenic injury Splenic Sequestration. Vision Loss. Leg Ulcers. DVT and PE. Other Possible Complications. Links to Other Websites. People with sickle cell disease (SCD) start to have signs of the disease during the first year of life, usually around 5 months of age. Symptoms and complications of SCD are different for each person and can range from mild to severe Arterial dissection is defined as cleavage of the arterial wall by an intramural hematoma between two elastic layers [].Isolated arterial dissection, which occurs without aortic dissection, has been reported in carotid and renal arteries but rarely in visceral arteries [].Spontaneous dissection of a visceral artery is an uncommon occurrence that is usually diagnosed after fatal hemorrhage or. Antiphospholipid syndrome 1. ANTIPHOSPHOLIPID SYNDROME (APS) Dr Saurabh Gupta PG medicine VMMC AND SJH 2. INTRODUCTION THROMBOSIS IS HEMOSTASIS IN WRONG PLACE Antiphospholid syndrome(APS) is an autoimmune disorder which manifests clinically as recurrent arterial or venous thrombosis and/or fetal loss Splenic abscess is an uncommon disease, and it has been noted to occur at a rate of 0.14% to 0.7% in autopy studies. 1, 2 Splenic abscesses generally occur in patients with neoplasia, immunodeficiency, trauma, metastatic infection, splenic infarct or diabetes. 3 The incidence of splenic abscess is thought to be growing, due to the increasing number of immunocompromised patients who are. CT scan of the thorax and abdomen was performed, which showed bilateral small pleural effusions, larger on the left and an unexpected finding of thrombosis in the branches of the splenic vein, and an enlarged spleen measuring 14.9 cm, within which were multiple areas of hypoperfusion, suggestive of splenic infarcts. Blood cultures were negative.